Official
start of the DENFRAME project: November
2005
Last
DENFRAME general meeting: 16-17 October, 2008
WP
1:
Start
of recruitment:
May 2006
Patient
Inclusion:
Recruitment is finished in Asia. Data entry is ongoing
and should be completed in February 2007.
Patient inclusion has been low in Latin America due to
a period of low circulation of dengue virus. A prolongation
of the recruiting period to June 2007 has been organized
in Brazil and French Guiana.
Data
analysis:
Database cleaning and univariate analysis on the two Asian
sites will start in February 2007. Database should be
locked for the four sites in July 2007 for pooled analysis.
WP
2:
The protocols for isolation, genome detection and serological
diagnosis of dengue virus infection used in the four sites
have been validated.
Protocols
for serological diagnosis (IgG and IgM) of dengue virus
infection are standardized.
Regional
training and technological transfer for dengue and other
arboviruses standardized current diagnostic assays are
done.
WP 3:
New reagents (two recombinant proteins) used for biological
diagnosis of dengue viruses are developed and will be
tested using ELISA methods and chemioluminescent biosensors.
DENFRAME
General Meeting:
A meeting with the 13 institutions involved in the DENFRAME
consortium happened from 8 to 10 March 2007 at the Institut
Pasteur (Paris, France).
Meetings
